Partner 12A - Institut National de la Recherche Agronomique
Contact person
University and research group information
- UMR 1089 Xénobiotiques is part of the Human Nutrition department of INRA, the French National Institute for Research in Agronomy.
- The department research focus on Human nutrition and food safety
- The UMR ('Joint Research Unit') comprises 22 scientists, 5 teachers and 15 technicians. It is located at the INRA Laboratory of Xenobiotics and at the National Veterinary School of Toulouse.
The main research areas of UMR 1089 are:
- The transfer of xenobiotics along the food chain (absorption, transport, metabolism, elimination, residue identification, formation of toxic metabolites).
- Xeno-biochemistry: enzymology, modulation of enzyme expression, comparative metabolism.
- Environmental toxicology: metabolism and mode of action of endocrine disruptors.
- Metabolic toxicology: formation of DNA adducts.
- Research for biomarkers of oxidative stress.
- Dietary factors modulating colorectal carcinogenesis.
Tools
- HPLC an radio-HPLC; Micro-HPLC
- UV, IR and fluo-HPLC, Capillary Electrophoresis
- MS and MSn, LC and GC-MS
- NMR (600 Mhz), LC-NMR
- MAB-TOF
Contribution to CASCADE
Within the CASCADE Network, UMR 1089 main task is to investigate the metabolic fate of selected chemicals and model compounds, with the aim to achieve a clear understanding of the structures able to trigger a biological response in in vivo and in vitro models. Xenobiotic biotransformation are being studied in tight collaboration with CASCADE network partners using selected experimental models.
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